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Does delta eight block your delta nine receptor. after smoking delta eight it seems that delta nine does not work as effectively

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the cb1 receptor is activated by both

Dave-Bratcher:

I think that is a great question. I don't think that there is a delta-8 or delta-9 receptor strictly speaking, but both compounds have been shown to interact with our endocannabinoid system similarly. Where they differ is where the double bond is located (8th carbon for delta 8 and 9th carbon for 9) this is what is thought to make delta-8 much less potent than regular THC. Hope this helps in a round-about sort of way. Happy toking!

Dave-Bratcher:

Charles-DeClouette: I think that is a great question. I don't think that there is a delta-8 or delta-9 receptor strictly speaking, but both compounds have been shown to interact with our endocannabinoid system similarly. Where they differ is where the double bond is located (8th carbon for delta 8 and 9th carbon for 9) this is what is thought to make delta-8 much less potent than regular THC. Hope this helps in a round-about sort of way. Happy toking!

There are 2 primary categories that bind to canabinoids- the CB1 and CB2 receptors. There are subreceptor types, as well, tho I am not sure how many and GENERALLY they have little difference in what activates each, so effectively they're the same for something like this.

However, as Dave states, D8 is less potent than D9. D10 is ALSO less potent than D9 AND D8. There are a few other Delta states, as well as "salt" forms (such as THC-oxo-Acetate (THCO) exist for almost all of those. The Delta forms start at d7 (If you have any tolerance, it is not psychoactive but will show as exposure if being tested) D8, 9, 10, 11. The most potent (and most prevalent) is D9. It can be made from CBD/CBN/CBG (the prodrug form of thc-v) via reflux in a .08 molar solution of hydrochloric acid and pyridine as the solvent. I can list more information but it isnt really relevant.

The THCs all bind to CB1 and 2 receptors, but CBD and CBN also bind to both, as does acetaminophen/paracetamol/tylenol but only to CB2 (I BELIEVE, its been a long time since I read the info)... Interestingly tylenol has been shown to reduce social anxiety at much higher a rate than placebo, and NEARLY as well as more addictive or dangerous than medications like SSRIs or Benzos. And, like those other medications, it is not recommended that alcohol be mixed with any of them, but tylenol can be much riskier than the others... depending on the dose. With tylenol, it has been shown that social anxiety treatment can be effectively minimized with a dose as low as 300mg (basically 1 regular strength tablet.)

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