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Why am I not affected by edibles?

Questions that Need Answers

Why am I not affected by edibles?

7
1987
3

Hello Bill!

I hope all is well. Interesting that you state you don't feel edibles. Can you describe what products you are consuming? Usually a 10MG THC edible will hit an avid smoker. I am curious about what product you are using and what you feel. (Not medical advice ; just a conversation)

Hi Bill, without insinuating anything, how would you consider your overall mental health? There are some interesting interaction effects with some 'disorders', like bipolar 2, for example. The data are sparse, but anecdotally I have experienced it in several cases (I'm a neuropsychopharmacologist by training). Also, you could have some enzymes in your liver that break down the cannabinoids faster than a typical user. Have you tried tinctures or other routes of administration that do not require oral consumption?

Hello Jason,

No offense taken reagrading my mental health. I don’t have any ‘disorders’ besides imho the overall anxiety/depression the pandemic has brought upon many of us. I experienced the effect that edibles have had upon me for a number of years. Tinctures such as RSO when placed under my tongue do effect me but ingested edibles or infused beverages don’t at all. Your comments regarding enzymes have been mentioned to me in the past but I did not investigate further at the time. Could you explain the difference to me regarding ingested edibles vs tincture place under my tongue?

Jason-Rogers: Hi Bill, without insinuating anything, how would you consider your overall mental health? There are some interesting interaction effects with some 'disorders', like bipolar 2, for example. The data are sparse, but anecdotally I have experienced it in several cases (I'm a neuropsychopharmacologist by training). Also, you could have some enzymes in your liver that break down the cannabinoids faster than a typical user. Have you tried tinctures or other routes of administration that do not require oral consumption?

Ooo I know this one!!

Take it from a former Budtender (me) who had to answer this question ALL the time...research shows that some people literally lack the specific enzyme in their digestive system that turns THC into the metabolic byproduct 11-hydroxy-THC which is what gives you the intoxicating effects when consuming a THC edible.

Check this out...

"11-hydroxy-THC, a metabolic byproduct created as the THC in your edible passes through your GI tract and liver. Metabolic enzymes modify and break down the compounds in the foods we eat. The metabolic byproducts of this process are usually less active than the original molecule. However, in the case of 11-hydroxy-THC, the metabolite is actually more potent than its progenitor, THC.

An early study compared the effects of THC and 11-hydroxy-THC. The researchers found that when volunteers were given equivalent one-milligram doses intravenously of either compound, 11-hydroxy-THC resulted in a faster onset and a more intense psychoactive experience than THC." - Source

CRAZY right?! A coworker of mine could drink a 1000mg drink followed by a 1000mg Candybar (not recommended by any means but witnessed) and not feel a thing...ever! I on the other hand start to nod off after a micro-dose of 2.5 mg, no intoxicating effects, just damn tired lol.

As with most other ways of consuming, THC affects different people...differently.

Thank you Shannon. I have the same reaction as your co worker so believe it is the enzyme but wondering why I can feel the effects of RSO when placed under my tongue or gums?

Shannon-Parkhill-256563: Ooo I know this one!!

Take it from a former Budtender (me) who had to answer this question ALL the time...research shows that some people literally lack the specific enzyme in their digestive system that turns THC into the metabolic byproduct 11-hydroxy-THC which is what gives you the intoxicating effects when consuming a THC edible.

Check this out...

"11-hydroxy-THC, a metabolic byproduct created as the THC in your edible passes through your GI tract and liver. Metabolic enzymes modify and break down the compounds in the foods we eat. The metabolic byproducts of this process are usually less active than the original molecule. However, in the case of 11-hydroxy-THC, the metabolite is actually more potent than its progenitor, THC.

An early study compared the effects of THC and 11-hydroxy-THC. The researchers found that when volunteers were given equivalent one-milligram doses intravenously of either compound, 11-hydroxy-THC resulted in a faster onset and a more intense psychoactive experience than THC." - Source

CRAZY right?! A coworker of mine could drink a 1000mg drink followed by a 1000mg Candybar (not recommended by any means but witnessed) and not feel a thing...ever! I on the other hand start to nod off after a micro-dose of 2.5 mg, no intoxicating effects, just damn tired lol.

As with most other ways of consuming, THC affects different people...differently.

Hi Bill,

It sounds like we have an answer (thanks, Shannon!). To answer your question, Bill, sublingual administration, i.e., tinctures like RSO, are absorbed under the tongue through the lining of the mouth. It skips the GI tract and liver altogether (and therefore the conversion of delta-9-THC to 11-hydroxy-THC). This is quite similar to buccal administration through the cheek and gums (think chew/dip). That is why they tend to absorb and set in much faster.

Here is an excellent article that might help: https://highthere.com/cannabis/edibles/why-no-high/

Thanks for the question and the discussion!

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